Zelnorm
The prescription drug Zelnorm, used to treat irritable bowel syndrome in women, was removed from the market by the FDA on April 2, 2007. Studies showed the use of the drug could cause serious cardiovascular events, including severe angina, heart attacks and strokes. Results have also shown that Zelnorm may be responsible for severe cases of diarrhea, ischemic colitis and some deaths.
Initially, Zelnorm was shown to increase the movement of stools through the bowels, and was thought to help women under age 65 suffering from irritable bowel syndrome coupled with constipation. It was shown to have no effect on men, and was therefore not prescribed to them. Zelnorm had also been shown to help in the treatment of ischemic colitis and irritable bowel syndrome with diarrhea.
Before it's recall, Zelnorm was prescribed to about 500,000 people. In 2006 it generated just under five hundred million dollars in revenues for its manufacturer, Novartis.
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